MENTAL MODEL · M0718

Seven Relations of Prescribing

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Version 1.0.0 · Updated 2026-07-30

CORE DEFINITION

Seven relationships among drugs: single action, mutual reinforcement (synergy), mutual assistance (adjuvant), mutual restraint (toxicity reduction), mutual detoxification (antidote), mutual antagonism (cancellation), and mutual opposition (toxicity increase).

SCAFFOLDING EFFECT

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Chemical reaction table. Before combining two drugs, consult the table. Is it to enhance potency (mutual reinforcement) or to detoxify (mutual detoxification)? Strictly avoid 'mutual antagonism' (undermining each other) and 'mutual opposition' (explosion).

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In Chinese herbal compounding, the seven relationships—single action, mutual reinforcement, mutual assistance, mutual restraint, mutual detoxification, mutual antagonism, and mutual opposition—determine whether drug combinations enhance efficacy or increase toxicity, guiding safe formulation.

MINIMUM ACTION

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Practice this model in one real situation:

Identify the compatibility relationship of each drug in the formula. 2. Use mutual reinforcement and mutual assistance to enhance efficacy. 3. Use mutual restraint and mutual detoxification to reduce toxicity. 4. Avoid mutual antagonism and mutual opposition to prevent reduced efficacy and increased toxicity.

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baike.baidu.comhttps://baike.baidu.com/item/%E4%B8%83%E6%83%85%E9%85%8D%E4%BC%8D/4530825ZH · Explicit
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